Name:                 Tuck Wah Soong  
Appointment:         Professor
Nationality:           Singapore citizen
Marital Status:       Married (2 children)
  • BSc (Hons), 1983, Microbiology (National University of Singapore)
  • PhD, 1992, Molecular Immunology (Institute of Molecular and Cell Biology, National University of Singapore)
  • Singapore Chinese Chamber of Commerce and Industry, 1980-81
  • Beecham (NUS Scholarship), 1981-82
  • Beecham (NUS Scholarship), 1982-83
  • IMCB postdoctoral Fellowship 1992-1995
  • NMRC Medical Research Scientist Award 1999 (Visiting Scientist, Johns Hopkins University)
  • AlbertaHeritage Foundation Medical Research (Visiting Lecture Award, June 2005)
  • UK-Singapore Partners in Science Collaboration Award, June 2006
  • YongLoo Lin Schoolof Medicine Research Excellence Award, 2005/06
  • NUHS AMDA Award 2011
  • NGS Teaching Commendation Award 2012
  • Swee-Liew Wadsworth Research Award, (Gold:  2012 (2); 2015)
  • WHB-SMA Outstanding Mentor Award, 2012
  • WHB-SMA Outstanding Mentor Award, 2013
  • Singapore Neuroscience Association (“Excellence in Neuroscience Research Award” 2013)
  • Yong Loo Lin School of Medicine Research Excellence (Award, 2012/13)
  • Yong Loo Lin School of Medicine Outstanding Research (Award, 2014/15)
  • Association for the study of Neuron and Disease, AND Investigator award, 2016
  • Dr C.S. Paulose Research Excellence Award, India, 2016                                             
Working Experience:
  • Predoctoral Fellow at Imperial Cancer Research Fund,  London, England  1986 to 1987 (Prof Michael J Owen).
  • PhD student, Institute of Molecular and Cell Biology, National University of Singapore, 1987-1991 (A/Prof Hui Kam Man).
  • Postdoctoral Fellow at University of British Columbia, Vancouver, Canada, 1992 to 1995 (Prof Terry Snutch).
  • Research Associate, IMCB Singapore, 1996-1999  (A/Prof Wang Yue)
  • Visiting Scientist, The Johns Hopkins University School of Medicine, Dept. of Physiology, Baltimore, USA, 1999-2000 (Prof William Agnew).
  • Principal Investigator & Head Ion Channel & Transporter Laboratory, National Neuroscience Institute, 1999-
  • Assistant Dean, Education (Life Sciences) Yong Loo Lin School of Medicine, NUS, 2006- 2008
  • Associate Professor, Department of Physiology, National University of Singapore (NUS) 2004- 2014
  • Professor, Department of Physiology, National University of Singapore (NUS) 2015-
  • Head of Department, Department of Physiology, National University of Singapore (NUS) 2008-
Cross Appointments:
  •  Distinguished Visiting Scientist, National Neuroscience Institute, October 2012-
  • Research Associate, Biomedical Engineering Dept, Johns Hopkins University School of Medicine, 2001-
  • Senior Faculty Member, NUS Graduate School for Integrative Sciences and Engineering (NGS); 2004-
  • EXCO member, NGS, 2010-2013
  • Group Leader, Neurobiology and Ageing Group, National University of Singapore, 2004-
  • IMH Scientific Advisory Board, 2009
  • Invitation as member of Advisory Panel for the Center for Neural Science of the Korea Institute of Science and Technology, KIST, 2 December 2008
  • President, SfN Singapore Chapter, 2009-2011
  • Invitation as International Scientific Review Member for the Institute for Biomedical Sciences, Academia Sinica, Taiwan, 6-9 March 2013
  • Chairman, Organizing Committee 8th International Conference on Neurons and Brain Diseases, July 2-4, 2013
  • Co-chair, National Medical Research Council, CBRG local grant review panel, 2012-2016
Editorial Board:  
  • Molecular Brain: Editorial Board Member, 2006-2014 Section Editor, 2014-
  • Frontiers in Pharmacology of Ion Channel and Channelopathies: Associate Editor, 2010-
  • Channels: Editorial Board Member, 2012-
  • PLoS One: Academic Editor, 2014-
  • Frontiers in Cellular Neuroscience: Reviewing Editor, 2015
  • Matters: Editorial Board, 2016
(1) Journals - International
(1.1) B. Flanagan, D. Wotton, T. W. Soong, and M. J. Owen.
DNase hypersensitivity and methylation of the human CD3 G and D genes during T-cell development.
Immunogenetics, USA, (1990) 31: 13-20.
(1.2) T. W. Soong and K. M. Hui.
Regulation of the expression of major histocompatibility complex class I genes in human colorectal cancer cells.
Cancer Detection and Prevention, USA, (1991) 15: 231-239.
(1.3) T. W. Soong, A. A. Oei, and K. M. Hui.
Regulation of HLA class I gene expression in human colorectal carcinoma.
Seminars in Cancer Biology, USA, (1991) 2: 23-33.
(1.4) T. W. Soong, and K. M. Hui.
Identification of locus-specific DNA-binding factors for the regulation of HLA
class I genes in human colorectal cancer.
Int. J. Cancer(S), USA, (1991) 6: 131-137.
(1.5) T. W. Soong, and K. M. Hui.
Locus-specific transcriptional control of HLA genes.
J. Immunology, USA, (1992) 149: 2008-2020.
(1.6) J.L. Bidwell, T.W. Soong, P.A. Raymond, D.G. Doherty, and K.M. Hui.
HLA genotyping of colorectal carcinoma in the Chinese population.
Hum Immunol, USA, (1992) 34: 19-23.
(1.7) T. W. Soong, A. Stea, C. D. Hodson, S. J. Dubel, S. R. Vincent, and T. P.Snutch.
Structure and Functional Expression of a Member of the Low Voltage-activated Calcium Channel Family.
Science, USA, (1993) 260: 1133-1136.
(1.8) A. Stea, W.J. Tomlinson, T.W.Soong, E. Bourinet, S.J.Dubel, S.R. Vincent, and T.P. Snutch. 
Localization and functional properties of a rat brain 1A calcium channel reflect similarities to neuronal Q- and P- type channels.
Proc. Natl. Acad. Sci., USA, (1994), 91(22) : 10576-80.
(1.9) C.T. Yokoyama, R.E. Westenbrook, J.W. Hell, T.W. Soong, T.P. Snutch, and W.A. Catterall.
Biochemical properties and subcellular distribution of the neuronal class E
calcium channel a1 subunit.
J. Neurosci., U,S,A., (1995), 15: 6419-6432
(1.10) M. de Leon, Y Wang, L.Jones, E. Perez-Reyes. X. Wei, T.W. Soong, T.P. Snutch, and D.T. Yue.
An essential structural domain for Ca-sensitive inactivation of L-type Ca channels.
Science, U.S.A., (1995), 270: 1502-1506.
(1.11) A. Stea, T.W. Soong, and T.P. Snutch.
Determination of PKC-dependent modulation of a family of neuronal calcium channels.
Neuron, U.S.A., Oct  (1995),15: 929-940.
(1.12) E. Bourinet, T.W. Soong, A.Stea, and T.P. Snutch.
Determinants of the G-protein-dependent opoid modulation of neuronal calcium channels.
Proc. Natl. Acad. Sci., U.S.A., (1996),93: 1486-1491.
(1.13) G.W. Zamponi, T.W.Soong, E. Bourinet, and T.P. Snutch.
bsubunit coexpression and a1 subunit domain I-II linker affect piperidine binding to neuronal calcium channels.
J. Neurosci. (1996), 16: 2430-2443.
(1.14) E. Bourinet, G.W. Zamponi, A. Stea, T.W. Soong, B.A. Lewis, L.P. Jones, D.T.Yue,  and T.P. Snutch.
The alpha 1E calcium channel exhibits permeation properties similar to low voltage activated calcium channels.
J. Neurosci. (1996), 16: 4983-4993.
(1.15) W.H. Yap, X. Li, T.W. Soong, and J.E. Davies.
Genetic diversity of soil microorganisms assessed by analysis of hsp70(dnaK) sequences.
JIM, (1996) 17:179-184.
(1.16) E. Bourinet*, T. W. Soong*, K. Sutton, S. Slaymaker, E.Mathews, A. Monteil, G. W. Zamponi, J. Nargoet, and T.P. Snutch.
Splicing of a1A subunit gene generates phenotypic variants of P- and Q-type calcium channels.
Nat. Neurosci. (1999) 2: 407-415. * joint first author
(1.17) T. W. Soong, T. F. Yong. N. Ramanan, and Y. Wang.
Candida albicans Na+/H+ antiporter gene, CNH1, has a role in salt-tolerance, morphogenesis and pathogenesis.
Microbiology, (2000);146:1034-44.
(1.18) L. Zhang, T. Lee, Y. Wang, and T. W. Soong
Heterologous expression, functional characterization and localization of two isoforms of monkey iron transporter.
Biochemical Journal2000; 349: 289-297.
(1.19) DeMaria CD, Soong TW, Alseikhan BA, Alvania RS, and Yue DT
Calmodulin bifurcates the local Ca2+ signal that modulates P/Q-type Ca2+ channels.
Nature, (2001); 411: 484-489.
(1.20) Soong TW, DeMaria CD, Alvania RS, Zweifel, LS, Liang MC, Mittman S, Agnew WS and Yue DT.
Systematic identification of splice variants in human P/Q-type (Cav2.1) channels:    Implications for current density and Ca2+-dependent inactivation.
J.Neurosci, (2002); 22:10142-10152
(1.21) F TSANG1, & TW Soong
Interactions between environmental and genetic factors in the pathophysiology of Parkinson’s disease
IUBMB Life, 55(6): 323–327, June 2003, Review.
(1.22) Chaudhuri D, Chang SY, Demaria CD, Alvania RS, Soong TW and Yue DT
Splice variation functions as a molecular switch for Ca2+/calmodulin-dependent facilitation of P/Q-type Ca2+ channels.
J Neurosci.,2004, 24(28):6334-6342.
(1.23) Tang ZZ, Liang MC, Lu SQ, Yu D, Yu CY, YueDT and Soong TW.
Transcript-scanning reveals Novel and Extensive Splice Variations in Human L-type Voltage-gated Calcium Channel, Cav1.2 a1-subunit.
J. Biol Chem, 2004, 43: 44335-44343
(1.24) LiaoP, YuD, Lu SQ, Tang ZZ, Liang MC, Zeng S, Lim W, and Soong TW
Smooth muscle selective alternatively spliced exon generates functional variation in Cav1.2 calcium channels.
J. Biol Chem, 2004, 48:50329-5033.
(1.25) Liao P, Yong TF, Liang MC, Yue DT, Soong TW
             Splicing for alternative structures of Cav1.2 Ca2+ channels in cardiac and smooth muscles.
             Cardiovasc Res. 2005 Nov 1;68(2):197-203. Epub 2005 Jul 27.
(1.26) Chaudhari D, Alseikhan B, Chang SY, Soong TW and Yue DT
Developmental activation of calmodulin-dependent facilitation of cerebellar P-type Ca2+ current
J Neurosci.2005;25(36):8282-94.
(1.27) Wong E, Yu W, Yap WH, VenkateshB and Soong TW
Comparative genomics of the human and fugu voltage-gated calcium channel a1 subunit gene family reveals greater diversity in fugu
Gene, 2006, 366, 117-127.
(1.28)  Venkatesh B, Lu SQ, Dandona N, See SL, Brenner S, Soong TW
             Genetic basis of tetrodotoxin resistance in pufferfishes.
             Curr Biol. 2005 Nov 22;15(22):2069-72.
(1.29) Wang C, Ko HS, Thomas B, Tsang F, Chew KC, Tay SP, Ho MW, Lim TM, Soong TW,  Pletnikova O, Troncoso J, Dawson VL, Dawson TM, Lim KL. 
              Stress-induced Alterations in Parkin Solubility Promote Parkin Aggregation and Compromise Parkin's Protective Function.
Hum Mol Genet. 2005;14(24):3885-97.
(1.30) Tao J, Zhang Y, Soong TW, and Li S.
Urocortin II inhibits the apoptosis of mesenteric arterial smooth muscle cells via L-type calcium channels in spontaneously hypertensive rats.
Cell Physiol Biochem.2006;17(3-4):111-20. Epub 2006 Mar 14.
(1.31) Y Shen, D Yu, H Hiel, P Liao, DT Yue, PA Fuchs, and TW Soong
Alternative splicing of the CaV1.3 channel IQ domain¾a molecular switch for Ca2+-dependent inactivation within auditory hair cells.
             J Neurosci.2006 Oct 18;26(42):10690-9. 
(1.32) Tao J, Zhang Y, Soong TW, Li S. 
            Expression of Urocortin 2 and its Inhibitory Effects on Intracellular Ca(2+) Via L-Type Voltage-Gated Calcium Channels in Rat Pheochromocytoma (PC12) Cells.
            Neuropsychopharmacology. 2006 Dec;31(12):2600-9. Epub 2006 Jun 7.
(1.33) Soong TW and Venkatesh B
Adaptive evolution of tetrodotoxin resistance in animals
Trends Genet.2006 Nov;22(11):621-6. Epub 2006 Sep 7.
(1.34) Zhen Zhi Tang, Xin Hong, Jing Wang, and Tuck Wah Soong
Signature combinatorial splicing profiles of rat smooth- and cardiac-muscle Cav1.2 channels with distinct biophysical properties.
Cell Calcium; 2007, 41(5):417-428.
(1.35) Chang SY, Yong TF, Yu CY, Liang MC, Pletnikova O, Troncoso JC, Burgunder JM and Soong TW
Age and gender-dependent alternative splicing of P/Q-type calcium channel
Neuroscience, 2007, 145(3):1026-1036.
(1.36) Tao J, Lin M, Sha J, Tan G, Soong TW, Li S
Separate locations of urocortin and its receptors in mouse testis: function in male reproduction and the relevant mechanisms
Cell Physiol Biochem, 2007, 19(5-6): 303-12
(1.37) Tao J, Liang MC, Hildebrand ME, Tan G, Shen Y, Li S, Snutch, TP and Soong TW
Activation of corticotrophin-releasing factor receptor 1 selectively inhibits Cav3.2 T-type calcium channels
Mol Pharmacol, Jun 2008, 73(6): 1596-1609. (Faculty 1000/Biology)
(1.38) Liao P, Yu D, Li G, Yong TF, Soon JL, Chua YL and Soong TW
A smooth muscle Cav1.2 calcium channel splice variant underlies hyperpolarized window current and enhanced state-dependent inhibition by nifedipine
J. Biol Chem, . 2007 Nov 30, 282:35133-42
(1.39) Tang ZZ, Liao P, Li G, Jiang FL, Yu D, Hong X, Yong TF, Tan G, Lu S, Wang J, Soong TW.
Differential Splicing Patterns of L-type Calcium Channel Cav1.2 subunit in hearts of Spontaneously Hypertensive Rats and Wistar Kyoto Rats
BBA_MCR, 2008 Jan; 1783(1):118-30
(1.40) Yang H, Xia Y, Lu SQ, Soong TW, Feng ZW.
 BFGF-induced neuronal differentiation of mouse bone marrow stromal cells requires FGFR-1, MAPK/ERK and transcription factor AP-1.
J Biol Chem. 2008, Feb, 283(9):5287-95
(1.41) TaoJ, ZhangY, SunW, LiS,SoongTW
Tyrosine kinase-independent inhibition of genistein on T-type calcium channels in spermatogenic cells and regulates sperm functions in mice
Cell Calcium, 2009, 45(2):133-43
(1.42) Liao P, Zhang HY and Soong TW
               Alternative splicing of voltage-gated calcium channels: from molecular biology to disease.
Pflugers Arch. 2009 Jul;458(3):481-7, Jan 17 Epub
(1.43)  Liao P, Li G, Yu D, Lu SQ, Ong LN, Wang J, and Soong TW
Cardiac remodelling of Cav1.2 calcium channel splice variants in chronically infarcted left ventricle of rat heart.
Pflugers Arch. 2009 Aug;458(4):701-11
(1.44)  Tan BZ, Huang H, Lam R, Soong TW
Dynamic regulation of RNA editing of ion channels and receptors in the mammalian nervous system.
Mol Brain. 2009 May 29; 2(1):13
(1.45)  Pervushin K, Tan E, Parthasarathy K, Lin X, Jiang FL, Yu D, Vararattanavech A,  Soong TW, Liu DX, and Torres J
Structure and inhibition of the SARS coronavirus envelope protein ion channel       
PLoS Pathog. 2009 Jul;5(7):e1000511. Epub 2009 Jul 10.
(1.46) Chen J, Tao J, Zhang R, Xu Y, Soong TW, Li S.
               Urocortin inhibits mesenteric arterial remodeling in spontaneously hypertensive rats.
Peptides. 2009, Jun;30(6):1117-23. Epub 2009 Mar 6.
(1.47) Ryan DP, Dias da Silva MR, Soong TW, Fontaine B, Donaldson MR, Kung AW, Jongjaroenprasert W, Liang MC, Khoo DH, Cheah JS, Ho SC, Bernstein HS, Maciel RM, Brown RH and Ptacek L.
Mutations in a novel potassium channel (Kir2.6) causes susceptibility to thyrotoxic hypokalemic periodic paralysis.
Cell, 2010 Jan 8; 140(1):88-98. (Faculty 1000/Biology)
(1.48) Xu JH, Long L, Wang J, Tang YC, Hu HT, Soong TW, Tang FR
               Nuclear Localization of Ca(v)2.2 and its Distribution in the Mouse Central Nervous System, and Changes in the Hippocampus during and after Pilocarpine-induced Status Epilepticus.
Neuropathol Appl Neurobiol. 2010 Feb; 36(1):71-85
(1.49) Liao P, Soong TW
Ca(V)1.2 channelopathies: from arrhythmias to autism, bipolar disorder, and immunodeficiency.
Pflugers Arch.2010 Jul;460(2):353-9; 2009 Nov 15. [Epub ahead of print]
(1.50) Zhang HY, Liao P, Yu D and Soong TW
Alternative splicing modulates diltiazem sensitivtity of cardiac and smooth muscle Cav1.2 calcium channels
BJP, (2010), 160, 1631–1640
(1.51) Ang ET, Tai YK, Lo SQ, Seet R, Soong TW.
Neurodegenerative diseases:exercising toward neurogenesis and neuroregeneration.
Front Aging Neurosci.2010 Jul 21, 2:25
(1.52) Soon JL, Ping L, Chua YL, Soong TW, Sin KY.
Absence of calcium channel alpha1C-subunit mutation in human atrial fibrillation.
Asian Cardiovasc Thorac Ann.2010 Aug;18(4):349-53.
(1.53) Liao P and Soong TW
Understanding alternative splicing of Cav 1.2 calcium channels for a new approach towards individualized medicine
(1.54)Chew KC, Ang ET, Tai YK, Tsang F, Lo SQ, Ong E, Ong WY, Shen HM, Lim KL, Dawson VL, Dawson TM, Soong TW.
             Enhanced Autophagy from Chronic Toxicity of Iron  and Mutant A53T {alpha}-Synuclein: IMPLICATIONS FOR NEURONAL CELL DEATH IN PARKINSON DISEASE.
           J Biol Chem. 2011 Sep 23;286(38):33380-9
(1.55)Wang J, Thio SS, Yang SS, Yu D, Yu CY, Wong YP, Liao P, Li S, Soong TW.
          Splice Variant Specific Modulation of CaV1.2 Calcium Channel by Galectin-1 Regulates Arterial Constriction.
          Circ Res. 2011 Nov 11;109(11):1250-8
(1.56)Wu ZY, Yu DJ,Soong TW, Dawe GS, Bian JS.          
            Progesterone impairs human ether-a-go-go-related gene (HERG) trafficking by disruption of intracellular cholesterol homeostasis. 
           J Biol Chem.2011 Jun 24;286(25):22186-94
(1.57)Tan BZ, Jiang F, Tan MY, Yu D, Huang H, Shen Y, Soong TW.
           Functional characterization of alternative splicing in the C-terminus of L-type CaV1.3 channels.
           J Biol Chem. 2011 Dec 9;286(49):42725-35. [Epub ahead of print]
(1.58) Tan GM, Yu D, Wang J and Soong TW.
Alternative Splicing at C-terminus of CaV1.4 Calcium Channel Modulates Calcium-Dependent Inactivation, Activation Potential and Current Density.
J Biol Chem; 2012 Jan 6;287(2):832-47
(1.59) H Huang, BZ Tan, Y Shen, J Tao, F Jiang, YY Sung, CK Ng,  M Raida, G, Köhr, M Higuchi  H Fatemi-Shariatpanahi, DT Yue  and TW Soong
RNA editing of the IQ domain in Cav1.3 channels modulates their Ca2+-dependent inactivation
Neuron, 2012 Jan 26;73(2):304-16. (Faculty 1000/Biology)
(1.60)Gan S-W, Tan E, Lin X, Yu D, Wang J, Tan GM, Vararattanavech A, Yeo CY, Soon CH, Soong TW, Pervushin K and Torres J
              The Small Hydrophobic Protein Of The Human Respiratory Syncytial Virus Forms Pentameric Ion Channels
              J Biol Chem; 2012 Jul 13;287(29):24671-89. Epub 2012 May 23
(1.61) Navakkode S, Sajikumar S, Korte M and Soong TW.
Dopamine induces LTP differentially in apical and basal dendrites through BDNF and voltage dependent calcium channels.
Learn Mem., 2012 Jun 20;19(7):294-9
(1.62) Klionsky DJ et al
Guidelines for the use and interpretation of assays for monitoring autophagy.
Autophagy. 2012 Apr;8(4):445-544.
(1.63)PapanayotouC, Almeida ID, LiaoP, Oliveira NA, LuSQ, Kougioumtzidou, E, ZhuL, ShawA, ShengG, StreitA, YuD, SoongTW and SternCD
Calfacilitin: a novel calcium channel modulator essential for initiation of neural plate development
Nature Commun, 4, 1837, 14 May 2013
(1.64) Huang H, Yu D and Soong TW
C-terminal post-transcriptional modification of CaV1.3 channels distinctively modulates their dihydropyridine sensitivity
Mol Pharmacol, 2013 Oct;84(4):643-53
(1.65)Bazzazi H, Johny MB, Adams PJ, Soong TW and Yue DT
Continuosly tunable Ca2+ regulation of RNA-edited CaV1.3 channels
Cell Reports, 2013, Oct 31; 5:1-11. doi:10.1016/j.cell.rep2013.09.006
(1.66) KP Loh, G Ng, CY Yu, CK Fhu, D Yu, R Vennekens, B Nilius, TW Soong* and P Liao*
TRPM4 inhibition promotes angiogenesis after ischemic stroke
Pflugers Archive, 2014, Mar; 466 (3): 563-76.  *co-corresponding
(1.67) Huang H, Ng CY, Yu D, Zhai J, Lam Y and Soong TW
Modest CaV1.342-selective inhibition by compound 8 is b-subunit dependent
Nature Commun, 2014, Jul 24; 5:4481. (Faculty 1000/Prime)
(1.68) Woon PS, Sum MY, Kuswanto CN, Yang GL, Sitoh YY, Soong TW, Lee TS, Nowinski, WL, Sim K
             CACNA1C genomewide supported psychosis genetic variation affects cortical brain white matter integrity in Chinese patients withschizophrenia
J  Clin Psychiatry, 2014 Nov;75(11):e1284-90.
(1.69) Liao 
            Alternative splicing generates a novel truncated Cav1.2 channel in neonatal rat heart
            J Biol Chem,2015 Apr 3;290(14):9262-72, Feb 18.[Epub aheadof print]
(1.70) Kim YS, Kim YB, Kim WB, Yoon BE, Shen FY, Lee SW, Soong TW, Han HC, Colwell CS, Lee CJ, Kim YI.
           Histamine resets the circadian clock in the suprachiasmaticnucleus through the H1R-Ca(V) 1.3-RyR pathway in the mouse
           Eur J Neurosci. 2015 Oct;42(7):2467-77. doi: 10.1111/ejn.13030.
           [Epub ahead of print] PubMed PMID: 26215659.
(1.71) Sun ZJ, Ng KH, Liao P, Zhang Y, Ng JL, Liu ID, Tan PH, Chong SS, ChanYH, Liu J, Davila S, Heng CK, Jordan SC, Soong TW*, Yap HK*. (*co-lead authors)
          Genetic Interactions Between TRPC6 and NPHS1 Variants Affect Posttransplant Risk of Recurrent Focal Segmental Glomerulosclerosis.
          Am J Transplant.2015 Dec;15(12):3229-38. doi: 10.1111/ajt.13378.
(1.72)Soong TW, Mori MX.
            Post-transcriptional modifications and "Calmodulation" of voltage-gated calcium channel function: Reflections by two collaborators of David T. Yue
           Channels(Austin). 2015 Jun 8:0. [Epub ahead of print]
           PubMed PMID:26054929.
(1.73) Tai YK, Chew KC, Tan BWQ, Lim KL, Soong TW
            Iron mitigates DMT1-mediated manganese cytotoxicity via the ASK1-JNK signaling axis: Implications of iron supplementation for manganese toxicity
            Scientific Reports, 2016 Feb 16;6:21113. doi: 10.1038/srep21113
(1.74) Chan ES, Shetty MS, Sajikumar S, Chen S, Soong TW, Wong BS
            ApoE4 expression accelerates hippocampus-dependent cognitive deficits by enhancing Aβ impairment of insulin signaling in an Alzheimer's disease mouse model 
            Scientific Reports, 2016 May 18; 6:26119. Doi:10.1038/srep26119
(1.75) Tang W, Thevathasan JV, Lin Q, Lim KL, Lim, KB, Kuroda K, Bilger M, Soong TW, Fivaz M
Stimulation of Synaptic Vesicle Exocytosis by the Mental Disease Gene DISC1Is Mediated by N-Type Voltage-Gated Calcium Channels
                Front Synaptic Neurosci. 2016 Jun 14;8:15. doi: 10.3389/fnsyn.2016.00015
(1.76) Hu K, Wang JW, Yu D, Soon JL, de Kleijn DP, Foo R, Liao P, Colecraft, HM, Soong TW
Aberrant Splicing Promotes Proteasomal Degradation of L-type CaV1.2 Calcium Channels by Competitive Binding for CaVβ Subunits in Cardiac Hypertrophy
Scientific Reports, 2016 Oct 12;6:35247. doi: 10.1038/srep35247
(2) Book Chapters
(2.1) A, Stea T. W. Soong, and T. P. Snutch.
           Voltage-gated Calcium Channels
           CRC Handbook of Receptors and Channels
           CRC Press Inc, USA. (1994) 113-151
(2.2) F Tsang and T. W. Soong.
           Parkinson’s Disease: interplay between environmental and genetic factors In “Oxidative stress and neurodegenerative disorders”
           Chapter 26, 607-619
           Edited by G. Ali Wureshi and S. Hasan Parvez
           Elsevier Press, March 2007
(2.3) Shen YR, Sung YY and Soong TW
Alternative Splicing
Encyclopedia of Neuroscience
Springer Press, June 2009
(2.4) Huang H, Wang JJ and Soong TW
Splicing and editing to Customize CaV Channel Structures for Optimal Neural Function.
Chapter 13; 319-344
In “Modulation of Presynaptic Calcium Channels”.
Edited by Gary Stephens and Sumiko Mochida.
Springer Press, 2013. ISBN: 978-94-007-6333-3
(2.5) Huang H, Wang JJ and Soong TW
Alternative Exon Effect on Phenotype of CaV1.2 Channelopathy: Implications in Timothy Syndrome
Chapter 11; 205-224
In “Pathologies of Calcium Channels”.
Edited by Norbert Weiss and Alexandra Koschak
Springer Press, 2014. ISBN: 978-3-642-404281-4
(2.6) Jing Zhai,  Qingshu Lin, Zhenyu Hu, Ruixiong Wong, Tuck Wah Soong
Alternative Splicing and RNA Editing of Voltage-gated Ion Channels: Implications in Health and Disease; In press
In “Ion Channels in Health and Disease”.
Edited by Geoff Pitt/Michael Conn;
Academic Press/Elsevier, 2015

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