Department of Physiology, School of Medical Sciences, Universiti Sains Malaysia
16150 Kubang Kerian, , Kelantan Malaysia
Date of birth:
16 June 1969
PhD, Universiti Sains Malaysia (2007)
Area of Study: Physiology
Thesis: The expression of insulin-like growth factors and their receptors at preimplantation stage in reproductive tissue of diabetic mouse
M.Sc., Universiti Sains Malaysia (1999)
Area of Study: Physiology
Thesis: Studies on pseudopregnancy-associated hormonal profile, endometrial decidual growth and pregnancy outcome in streptozotocin-induced diabetic rats.
MBBS, University of Malaya, Malaysia (1994)
Area of Study: Medicine
Research Grant (as Principal Investigator)
Neuroprotective Effect of Tualang Honey in Male Rats Exposed to Hypobaric Hypoxia, USM (JANGKA PENDEK), RM44,610.00, 1/11/2014-31/10/2016
Potential mechanisms of cognitive impairment in Alzheimer’s disease rat model, KEMENTERIAN PENGAJIAN TINGGI (FRGS), RM156,022.00, 1/12/2014-30/11/2017
The Combined Effects of Ovariectomy and Chronic Social Instability Stress on Cognitive Functions, Depressive Behaviour and Biochemical Changes in Female Rats Tested with Tualang Honey, MINISTRY HEALTH OF OMAN, RM71,412.99, 1/9/2011-31/8/2014
The Effects of Tualang Honey on Psychological Functions Induced by Chronic Social Instability Stress in Ovariectomized Rats, USM (JANGKA PENDEK), RM37,998.00, 15/8/2011-14/8/2014
Year : 2009
The Effects Of Combination Behavioural Intervention Of Nutritional Education And Exercise (COMBINE) On Oxidate Stress Markers In Obese Subject, USM (RU), RM99,100.00, 1/4/2009-30/9/2011
Effects Of Tualang Honey On Cognitive Function And Oxidative Stress In Postmenopausal Women, USM (RU) , RM198,900.00, 1/1/2009-30/6/2012
Year : 2004
The Effect of Leptin on Pubertal Development in Male Rats, USM JANGKA PENDEK, RM18,092.00, 1/4/2004-30/9/2006
Year : 2002
The Role of Insulin-Like Growth Factor-I (IGF-I) in Diabetic Embryopathy, FRGS, RM91,260.00, 1/7/2002-31/12/2004
Research Grant (as Co-Researcher)
Determination Of Xanthine Oxidase Inhibitory Activity Of Medicinal Plants That Are Traditionally Used In Malaysia To Treat Gout And Identification Of Bioactive Phenolic Compounds, USM (RU), RM168,133.08, Shaida Fariza Binti Sulaiman, 31/12/2014-31/12/2017
Kinetic study and structure-activity relationship analysis of flavonol derivatives as alpha-glucosidase and alpha-amylase inhibitors, KEMENTERIAN PENGAJIAN TINGGI (FRGS), RM133,000.00, Shaida Fariza Binti Sulaiman, 1/12/2014-30/11/2017
Evalution of the Tualang Honey Neurobehavioural Effect in Young and Aged Male Rats with Noise Stress, USM (JANGKA PENDEK), RM39,924.00, Zahiruddin Bin Othman, 1/9/2014-31/8/2016
The role of oxidative stress and N-methyl-D-aspartate receptors in the mechanism of pain modulation in the offspring exposed to prenatal stress , KEMENTERIAN PENGAJIAN TINGGI (FRGS), RM147,440.00, Che Badariah Bt. Ab. Aziz , 1/7/2014-30/6/2017
Interventional Exercise Therapy On White Matter Connectivity ANd Motor Ability In Children With Cerebral Palsy : A Probabilistic Diffusion Tensor Imaging Study, USM (RU), RM138,781.23, Asma Hayati Bt Ahmad , 15/3/2014-14/3/2017
The Effects Of Tualang Honey On Peri-Menopausal Women , USM (RU), RM32,180.00, Nik Hazlina Binti Nik Hussain, 19/10/2007-17/4/2011
Role of Honey on Maternal Stress-Induced Effects on Reproductive Function and Neuronal Activity in Rat Offsprings , KEMENTERIAN PENGAJIAN TINGGI (FRGS), RM127,000.00, Mahaneem Binti Mohamed, 15/10/2007-15/10/2011
Evaluation of Chronic Effects of Leptin Administration on Testicular Functions, Body Weight and Feeding Behavior in Rats, J/PENDEK, RM0.00, Harbindar Jeet Singh A/l Gurcharan Singh, 15/11/2002-31/3/2006
Khairunnuur Fairuz Azman, Rahimah Zakaria, Che Badariah Ab Aziz, Zahiruddin Othman. Tualang Honey Attenuates Noise Stress-Induced Memory Deficits in Aged Rats. Oxidative Medicine and Cellular LongevityVolume 2016, Article ID 1549158, 11 pages. http://dx.doi.org/10.1155/2016/1549158
Asma Hayati Ahmad.and Rahimah Zakaria. Pain in Times of Stress. Malaysian Journal of Medical Sciences. Dec 2015; Special Issue: 52-61
Norulsuhada Munjir, Zahiruddin Othman, Rahimah Zakaria, Nazlahshaniza Shafin,Noor Aini Hussain, Anisah Mat Desa, Asma Hayati Ahmad. Equivalence and Practice Effect of Alternate Forms For Malay Version Of Auditory Verbal Learning Test (MAVLT). EXCLI Journal 2015;14:801-808
Zahiruddin Othman, Rahimah Zakaria, Nik Hazlina Nik Hussain, Asma’ Hassan, Nazlahshaniza Shafin, Badria Al-Rahbi, Asma Hayati Ahmad. Role of Tualang honey in Learning and Memory. Medical Sciences 2015; 3: 3- 15
Zahiruddin Othman, Nor Asyikin Fadzil, Rahimah Zakaria, Sharifah Zubaidiah Syed Jaapar and Maruzairi Husain.Religiosity in Malay Patients with HIV/AIDS: Correlation with Emotional Distress. Middle-East Journal of Scientific Research23 (2): 170-174, 2015
Khairunnuur Fairuz Azman, Rahimah Zakaria, Che Badariah Ab Aziz, Zahiruddin Othman, Badriya Al-RahbiTualang honey improves memory performance and decreases depressive-like behaviours in rats exposed to loud noise stress. Noise & Health 17(75) 83-89, 2015
Zahiruddin Othman, Siong Teck Wong, Ismail Drahman and Rahimah Zakaria. Caregiver Burden Is Associated with Cognitive Decline and Physical Disability of Elderly Post-Stroke Patients. Middle-East Journal of Scientific Research2014 22 (9): 1265-1271.
Srinivasan V, De Berardis D, Fornaro M, Lopez-Munoz F, Partonen T, Zakaria R. Mood disorders, sleep and circardian rhythm. Research and Advances in Psychiatry 2014; 1
Md Rizman Md Lazin @ Md Lazim, Rohana Abdul Jalil and Rahimah Zakaria.USM Behavioral Lifestyle Modification Program Reduces Lipid-Based cardiovascular Risk in Obese Adults: A Pilot StudyInternational Medical Journal2014Vol. 21, No. 6, pp. 1 - 4
Md Rizman Md Lazin @ Md Lazim, Rahimah Zakaria, Rohana AJ,Wan Suriati WN,Che Badariah AA, Asma Hayati Ahmad, Liza Noordin, Ainul Bahiyah Abu Bakar. Association of Changes in Body Composition with Changes in Systemic Oxidative Stress Following Weight Loss Program in Obese Adults Attending Obesity Clinic, Hospital Universiti Sains Malaysia. The Open Obesity Journal, 2014, 6, 60-64
Norsuhana O, Che Badariah AA, W.Zaidah A,Rohana AJ,Wan Suriati WN. Zakaria R. Reduced fibrinogen, fibrinolytic biomarkers, and physical parameters after a weight-loss program in obese subjects. North Am J Med Sci 6(8), 377, 2014
Badriya Al-Rahbi, Rahimah Zakaria, Zahiruddin Othman, Asma’ Hassan, and Asma Hayati Ahmad. Protective effects of Tualang honey against oxidative stress and anxiety-like behaviour in stressed ovariectomized rats. International Scholarly Research Notices Volume 2014, Article ID 521065, 10 pages, http://dx.doi.org/10.1155/2014/521065
Badriya Al-Rahbi, Rahimah Zakaria, Zahiruddin Othman, Asma’ Hassan, Asma Hayati Ahmad. The effects of Tualang Honey Supplement on Medial Prefrontal Cortex Morphology and Cholinergic System in Stressed Ovariectomised Rats. InternationalJournal of Applied Research in Natural Products. Vol. 7 (3), pp. 28-36, 2014
Venkataramanujam Srinivasan, Domenico De Berardis, Timo Partonen, Rahimah Zakaria, Zahiruddin OthmanThe use of melatonin for treating sleep disorders in patients with Parkinson’s disease. ChronoPhysiology and Therapy 2014:4 1-7
Nazlahshaniza Shafin, Rahimah Zakaria, Nik Hazlina Nik Hussain, Zahiruddin Othman. Improved blood oxidative status is not associated with better memory performance in postmenopausal women receiving Tualang honey supplementation. Journal of Biochemical and Pharmacological Research, Vol. 2 (3): 110-116, September 2014
Badriya Al-Rahbi, Rahimah Zakaria, Zahiruddin Othman, Asma’ Hassan, Asma Hayati Ahmad. Enhancement of the brain BDNF concentration and restoration of HPA axis reduce depressive-like behaviour in stressed ovariectomised rat treated with Tualang honey. The Scientific World Journal, vol. 2014, Article ID 310821, 8 pages, 2014. doi:10.1155/2014/310821.
Nizam Haron, Harbindar Jeet Singh, Urban J.A. D’Souza, Hasnan Jaafar and Rahimah Zakaria. Leptin administration decreases sperm count in Sprague-Dawley rats.Novus International Journal of Medical Science, 2013, Vol. 2, No. 1, 1-8
Badriya Al-Rahbi, Rahimah Zakaria, Zahiruddin Othman, Asma’ Hassan, Sangu Muthuraju, and Wan Mohd Zahiruddin Wan Mohammad. Mood and Memory Function in Ovariectomised Rats Exposed to Social Instability Stress. BioMed Research International Volume 2013 (2013), Article ID 493643, 10 pages
Badriya AL-RAHBI, Rahimah ZAKARIA, Sangu MUTHURAJU, Zahiruddin OTHMAN, Asma HASSAN. Preliminary Study: Effects of Social Instability Stress on Depressive Behaviours in Ovariectomised Rats. Malaysian Journal of Medical Sciences. 2013; 20(2):36-41
Venkataramanujam Srinivasan, Yoshiji Ohta, Javier Espino, José A. Pariente, Ana B.Rodríguez, Mahaneem Mohamed. Rahimah Zakaria. Metabolic Syndrome, its Pathophysiology and the Role of Melatonin Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 2013, 7, 11-25
Nazlahshaniza Shafin, Zakaria R, Nik Hazlina Nik Hussain, Zahiruddin Othman. Association of oxidative stress and memory performance in postmenopausal women receiving estrogen progestin therapy. Menopause. 2013 Jun;20(6):661-6. doi: 10.1097/GME.0b013e31827758c6.
V Srinivasan, Rahimah Zakaria, Zahiruddin Othman, Amnon Brzezinski. Melatonin, insomnia and the use of melatonergic drugs. Journal of Endocrinology and Reproduction. 2012; 16(1):15-24
V. Srinivasan, R. Zakaria, H. Jeet Singh, A. Castroviejo. Melatonin, its agonists in pain modulation: clinical application. Archives Italiennes de Biologie, 150: 274-289, 2012.
Venkataramanujan Srinivasan, Rahimah Zakaria, Zahiruddin Othman, Edward C. Lauterbach, Darío Acuña-Castroviejo. Agomelatine in Depressive Disorders: Its Novel Mechanisms of Action. The Journal of Neuropsychiatry and Clinical Neurosciences. 2012; 24(3):290-308.
Venkataramanujam Srinivasan, Asma H. Ahmad, Mahaneem Mohamed and Rahimah Zakaria. Melatonin Effects on Plasmodium Life Cycle: New Avenues for Therapeutic Approach Recent Patents on Endocrine, Metabolic & Immune Drug Discovery 2012, 6, 139-147
Venkataramanujam Srinivasan, Mahaneem Mohamed, Rahimah Zakaria and Asma Hayati Ahmad. Malaria, Anti Malarial Drugs and the Role of Melatonin Infectious Disorders – Drug Targets, 2012, 12, 371-379
Md Rizman Md Lazin @ Md Lazim, Rohana Abdul Jalil and Rahimah Zakaria.12-Week Behavioral Lifestyle Modification Program Increases Blood Antioxidant Enzyme Activities in Obese AdultsThe Open Obesity Journal, 2012, 4, 23-27
Venkatramanujam Srinivasan, Edward C. Lauterbach, Khek Yu Ho, Dario Acuna-Castroviejo, Rahimah Zakaria, Amnon Brzezinski. Melatonin in Antinociception: Its Therapeutic Applications. Current Neuropharmacology, 2012, 10, 167-178
Nik Hazlina Nik Hussain, Siti Amrah Sulaiman, Intan Idiana Hassan, Azidah Abdul Kadir, Norhayati Mohd Nor, Shaiful Bahari Ismail, Lili Husniati Yaacob, Rahimah Zakaria, Nazlah Shaniza Shafie, Juhara Haron, Kamarul Imran Musa. Randomized Controlled Trial on the Effects of Tualang Honey and Hormonal Replacement Therapy (HRT) on Cardiovascular Risk Factors, Hormonal Profiles and Bone Density Among Postmenopausal Women: A Pilot Study. Journal of Food Research May 2012Vol. 1, No. 2; 171-188
Salmi AA, Nik Zaki NM, Zakaria R, Nor Aliza AG, Aida HG Rasool. Arterial stiffness, inflammatory and pro-atherogenic markers in gestational diabetes mellitus.VASA- European Journal of Vascular Medicine (2012);41:96-104.
Lee SK, Sirajuddeen KNS, Arun K, Zakaria R, Singh HJ. Effect of cross-fostering on renal anti-oxidant⁄oxidant status and development of hypertension in spontaneously hypertensive rats. Clinical and Experimental Pharmacology and Physiology (2011) 38, 854–859
Zahiruddin Othman, Nazlahshaniza Shafin, Zakaria R, Nik Hazlina Nik Hussain, Wan Mohd Zahiruddin Wan Mohammad. Improvement in immediate memory after 16 weeks of tualang honey(Agro Mas) supplement in healthy postmenopausal women. Menopause (2011) 18(11): 1219-1224
Lee SK, Sirajuddeen KNS, Arun K, Zakaria R, Singh HJ. Effects of antenatal, postpartum and post-weaningmelatonin supplementation on blood pressure and renalantioxidant enzyme activities in spontaneously hypertensiverats. J Physiol Biochem (2011) 67:249-257
Mohd Nizam Haron, Urban J.A. D'Souza, Hasnan Jaafar, Zakaria R, Harbindar Jeet Singh. Exogenous leptin administration decreases sperm count and increases the fraction of abnormal sperm in adult rats, Fertility and Sterility (2010) 93 (1): 322-324
Zakaria R, Soriani Y, Rajikin MH, Norazmi MN. Immunolocalization of insulin-like growth factors and their receptors in the diabetic mouse oviduct and uterine tissues during the preimplantation period. Acta Histochemica (2009) 111: 52-60
Zakaria R, Soriani Y, Rajikin MH, Norazmi MN. Diabetes alters the mRNA expression of insulin-like growth factors and their receptors in the mouse fallopian tube and uterus during preimplantation stages. Reproductive Biology (2007) 7(1): 41-53.
Zakaria R, A Chatterjee, R Chatterjee. Insulin-like growth factor-1 and female fertility- A mini review. Biomedical Research2002; 13(2/3): 75-79.
Zakaria R, Z Ismail, A Chatterjee. Effects of diabetes on fetoplacental growth and fetal outcome in pregnant rats.Biomedical Research 2001; 12(2): 165-168.
Zakaria R, Chatterjee A. Growth hormone and reversal of the impaired endometrial decidual expression in streptozotocin-diabetic rats. Biomedical Research 2000; 11(3): 309-313.
Chatterjee A, Zakaria R. Mini review: Insulin deficiency and reproductive dysfunction in males: clinico-experimental verification. Biomedical Research 2000; 11(3): 277-282.
Zakaria R, Ismail Z, Chatterjee A. Cyproterone acetate and reversal of the impaired endometrial decidualization in streptozotocin diabetic pseudopregnant rats.Pharmacological Research 2000; 42: 183-186.
Zakaria R, Ismail Z, Chatterjee A. Equine chorionic gonadotropin and the reversal of streptozotocin-diabetes-linked impaired endometrial decidualization in pseudopregnant rats. Biomedical Research, 2000; 11(1): 43-47.
Zakaria R, Ismail Z, Chatterjee A. Does activation of ACTH-corticosterone axis impair endometrial decidualization in streptozotocin-diabetic pseudopregnant rats? Biomedical Research 1999; 10(2): 133-139.
Zakaria R., Ismail Z, Than M, Chatterjee A. Inappropriate ovarian estrogen and impaired endometrial decidualization in streptozotocin diabetic rats. Biomedical Research 1998; 9(3): 235-239.
Chatterjee A, Ismail Z, Zakaria R. Insulin deficiency and reproductive dysfunction in females: Experimental verification. Biomedical Research 1998; 9(2): 165-170.
Best Poster (1st prize): Siti Zubaidah Abdul Wahab, Nik Hazlina Nik Hussain, Azidah AbdulKadir , Rahimah Zakaria, Norhayati Mohd Noor, Intan Idiana Hassan, Siti Amrah Sulaiman.THE Effects Of Tualang Honey Versus Honey Cocktail On Psychosexual Changes And Quality Of Life Among Postmenopausal Women. 20th National Conference on Medical and Health Sciences, 12-14 Sept 2015
Best Poster (2nd prize): Siti Zubaidah Abdul Wahab, Nik Hazlina Nik Hussain, Azidah AbdulKadir , Rahimah Zakaria, Norhayati Mohd Noor, Intan Idiana Hassan, Siti Amrah Sulaiman. The Effects of Tualang Honey versus Honey Cocktail on Physiological, Hormonal changes and Bone Densitometry among Postmenopausal Women, 24th Asian and Oceanic Congress of Obstetrics and Gynaecology (AOCOG), "Old World Charm Meeting New Technology" Borneo Convention Centre, Kuching, Sarawak 3-6 June 2015
Best Poster. Khairunnuur Fairuz Azman, Rahimah Zakaria, Che Badariah Ab Aziz, Zahiruddin Othman, Badriya Al-Rahbi.Memory Performance and Brain Oxidative Status of Young and Old Rats: Efficiency of Tualang Honey Supplementation. National Conference on Ageing, Vistana Kuala Lumpur, 19-20 Nov 2014.
Pensyarah Pra Klinikal Pilihan Pelajar (wanita), PPSP USM (2015)
Khairunnuur Fairuz Binti Azman (PhD). Effects of Tualang honey on memory, depressive and anxiety behaviours, and biochemical changes in ageing male rats with social defeat stress. (graduated 2016)
Badriya Saleh AlRahbi (PhD). The combined effects of ovariectomy and chronic social instability stress on cognitive functions, depressive behaviour and biochemical changes in female rats treated with Tualang honey. (graduated 2013)
Wan Muhammad Hilmi Wan Yaacob (PhD) Effects of Ethanolic Extract of Tualang Honey on Learning and memory lmpairment in Alzheimer's Disease Rat Model
Lee Siew Keah (PhD) The effects of cross-fostering and melatonin supplementation on the oxidant status and development of hypertension in spontaneously hypertensive rats. (graduated 2011)
(ii) Master Degree (Research)
Dr Entesar Yaseen Abdo Qaid (MSc) Neuroprotective Effect of Tualang Honey in Male Rats Exposed to Hypobaric Hypoxia
Dr Md Rizman Md lazim (MSc)The effects of combined behavioural intervention of nutritional education and exercise (COMBINE) on oxidative stress markers in obese subjects (graduated 2013)
Dr Nazlah Shafin (Msc) Effects of Tualang Honey on cognitive function and oxidative stress in postmenopausal women (graduated 2013)
Salmi Bt Abdul Aziz (MSc) Arterial stiffness in gestational diabetes and its relationship to inflammatory and atherogenic markers. (graduated 2011)
Associate Professor, Department of Physiology,Universiti Sains Malaysia
Head of Physiology Department,Universiti Sains Malaysia
Senior Lecturer, Department of Physiology,Universiti Sains Malaysia
Lecturer, Department of Physiology,Universiti Sains Malaysia
Trainee Lecturer, Department of Physiology,Universiti Sains Malaysia